Promoter hypermethylation of death-associated protein kinase gene in cholangiocarcinoma

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BACKGROUND:Death-associated protein kinase(DAPK) is a Ca2+/calmodulin-regulated Ser/Thr kinase which is involved in apoptosis. The aberrant methylation of its promoter region CpG islands may be one of the important mechanisms of carcinogenesis. We studied
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