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目的建立大黄胶囊中大黄素和大黄酚的一测多评测定法。方法建立HPLC法测定大黄素与大黄酚间的相对校正因子,并应用于大黄胶囊,比较计算值与测得值的差异。结果用一测多评法对4批样品中大黄素和大黄酚进行测定,与外标法实测值基本一致。结论该方法可靠,结果准确,可用于大黄胶囊质量控制。
Objective To establish a multi-evaluation method for the determination of emodin and chrysophanol in rhubarb capsules. Methods To establish a HPLC method for the determination of relative correction factor between emodin and chrysophanol, and apply it to the rhubarb capsule to compare the differences between calculated and measured values. Results Multiple evalution methods were used to determine emodin and chrysophanol in four batches of samples. The results were in good agreement with the external standard method. Conclusion The method is reliable and accurate. It can be used for the quality control of rhubarb capsules.