充血性心力衰竭(congestive heart failure,CHF)常导致肺阻力血管重塑和张力增加,而这种适应性反应归因于肺内皮功能障碍,进而加重肺动脉高压,进一步促进右心室衰竭的发生。该文在通过结扎冠状动脉分支远端的主动脉而诱导的大鼠CHF实验模型中,研究者采用实时荧光成像技术检查内皮功能障碍及其可能的分子机 Congestive heart failure (CHF) often leads to vascular remodeling and tension increase of lung resistance, and this adaptive response is attributed to pulmonary endothelial dysfunction, which further aggravates pulmonary hypertension and further promotes right ventricular failure. In a rat CHF experimental model induced by ligation of the aorta distal to the coronary artery branch, the investigators used real-time fluorescence imaging to examine endothelial dysfunction and its possible molecular mechanisms