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咯萘啶(PND)是一种疟原虫红内期裂殖体杀灭剂,与氯喹无交叉抗性,对恶性疟和间日疟均有显著疗效。用家兔的初步实验表明,PND原药在尿中的排泄量仅约为剂量的2%。我们已报告该药在体内分布较广。文献报道PND对鼠疟原虫红内期裂殖体有长效作用。为进一步了解该药的体内过程,对~3H-PND在小鼠体内的分布和排泄进行了研究。
Pyronaridine (PND) is a malaria parasite erythrocytic schizophrenic agent that has no cross-resistance with chloroquine and has a significant effect on falciparum malaria and Plasmodium vivax. Preliminary experiments with rabbits showed that the original PND excretion in urine was only about 2% of the dose. We have reported that the drug is widely distributed in the body. It has been reported in the literature that PND has a long-term effect on the red-mid-term schizonts of Plasmodium. To further understand the in vivo process of this drug, the distribution and excretion of ~ 3H-PND in mice was studied.