Observation sentences result from the activation of sensory receptors,but even under the same stimulus the same observation sentence could be translated into different sentences by different translators for the differences in understanding of pronunciation and orientation of native speakers and in application of empathy in course of translation.The thesis of indeterminacy of translation principally belongs to the area of philosophy of language.The indeterminacy of observation sentances’ translation naturally leads to the inscrutability of reference of terms involved,and so different manuals of translation could assign different referents to one same word.However,the thesis of inscrutability of reference is a topic in the category of ontology,and people can select different theoretic frames of ontology for pragmatic purposes,wherein the reification of similar stimulations could produce different objective reference at all and comes the inscrutability of reference of one same word in different ontologies,as could be explicated completely by proxy functions.The thesis of underdetermination of scientific theory is another topic,which falls into the domain of theory of knowledge.Scientific theory is underdetermined by empirical content.Even logically incompatible,different scientific theories can absolutely be empirically equivalent.The argument is a scientific theory implies lots of observation categoricals,the latter’s failure(if any) does not determine one and only revision,and scientists can select any belief in the conjunction which implies the observation categorical in question to rescind or revise;of course,when applying this holistic strategy,the two pragmatic maxims of maximization of simplicity and minimization of mutilation should be insisted on.The above argument shows that scientific theory faces experience as a whole,or in other words,only as a whole could scientific theory have empirical meanings.Hence scientific theory with same empirical content can have different theory formulations and scientific theory is underdetermined(by empirical content) in this sense. Observation sentences result from the activation of sensory receptors, but even under the same stimulus the same vision sentence could be be converted into different sentences by different translators for the differences in understanding in pronunciation and orientation of native speakers and in application of empathy in course of translation The thesis of indeterminacy of translation principally belongs to the area of ​​philosophy of language. The indeterminacy of observation sentances’ translation of leads to the inscrutability of reference of terms involved, and so different manuals of translation could assign different referents to one same word. However, the thesis of inscrutability of reference is a topic in the category of ontology, and people can select different theoretic frames of ontology for pragmatic purposes, where the reification of similar stimulations could produce different objective reference at all and comes the inscrutability of reference of one same word in dif ferent ontologies, as could be explicated completely by proxy functions. The research of underdetermination of scientific theory is another topic, which falls into the domain of theory of knowledge. Scientific theory is underdetermined by empirical content. Even logically incompatible, different scientificightscan be empirically equivalent. The argument is a scientific theory implies lots of observation categoricals, the latter’s failure (if any) does not determine one and only revision, and scientists can select any belief in the conjunction which implies the observation categorical in question to rescind or revise; of course, when applying this holistic strategy, the two pragmatic maxims of maximization of simplicity and minimization of mutilation should be insisted on. The above argument shows that scientific theory faces experience as a whole, or in other words, only as a whole could scientific theory have empirical meanings. Health scientific theory with same empirical content can have different theory formulations and scientific theory is underdetermined (by empirical content) in this sense.