目的探讨腹腔镜联合大剂量甲氨蝶呤治疗宫外孕的效果。方法 100例宫外孕患者,随机分为观察组和对照组,各50例。对照组患者使用腹腔镜联合常规剂量甲氨蝶呤进行治疗,观察组患者使用腹腔镜联合大剂量甲氨蝶呤进行治疗,在治疗完成后比较两组患者的治疗效果以及患者对治疗的满意程度。结果两组患者经过治疗后均有所好转,但观察组患者的治疗效果明显优于对照组患者,观察组患者治疗总有效率98%明显由于对照组患者的治疗总有效率80%,同时观察组患者对治疗的满意程度评分(8.52±1.48)分明显优于对照组患者对治疗的满意程度评分(5.02±1.13)分。差异有统计学意义(P<0.05)。结论在对宫外孕患者进行治疗的过程中,使用腹腔镜联合大剂量甲氨蝶呤的方法效果更佳,在临床上值得推广应用。 Objective To investigate the effect of laparoscopy combined with high-dose methotrexate in the treatment of ectopic pregnancy. Methods 100 cases of ectopic pregnancy were randomly divided into observation group and control group, 50 cases each. Patients in the control group were treated with laparoscopy combined with conventional methotrexate. The patients in the observation group were treated with laparoscopy combined with high-dose methotrexate. After the treatment was completed, the treatment effect was compared between the two groups and the patient’s satisfaction with the treatment . Results Both groups were improved after treatment, but the treatment group in observation group was significantly better than the control group. The total effective rate in observation group was 98%. Obviously, the total effective rate in control group was 80% The satisfaction score of the patients in treatment group (8.52 ± 1.48) was significantly better than that in control group (5.02 ± 1.13). The difference was statistically significant (P <0.05). Conclusion In the treatment of patients with ectopic pregnancy, the use of laparoscopy combined with high-dose methotrexate is more effective and worthy of clinical application.