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目的探讨伊曲康唑联合硝酸咪康唑栓治疗念珠菌性外阴阴道炎(VVc)的效果,对易感因素进行分析,为临床治疗VVc提供参考。方法 480例患者随机分为研究组与对照组,每组各240例,研究组给予伊曲康唑口服400mg/d,连用7天,同时用硝酸咪康唑栓(400mg/枚)每晚放入阴道深部,连用7天;对照组单用硝酸咪康唑栓治疗,连用7天。结果研究组在7天、28天痊愈率与显效率明显高于对照组(P<0.05);对照组28天无效率明显高于研究组(P<0.05)。结论伊曲康唑联合硝酸咪康唑栓治疗VVc比单用硝酸咪康唑栓临床效果更好,复发率更低,值得临床推广应用。
Objective To investigate the efficacy of itraconazole combined with miconazole nitrate suppository in the treatment of Candida vulgaris vaginitis (VVc), analyze the susceptibility factors and provide a reference for the clinical treatment of VVc. Methods 480 patients were randomly divided into study group and control group, 240 cases in each group. The study group was given itraconazole orally 400mg / d for 7 days. Meanwhile, miconazole nitrate suppository (400mg / tablet) was put into the vagina every night Deep, used in conjunction for 7 days; control group treated with miconazole nitrate alone, once every 7 days. Results The cure rate and effective rate of the study group at 7 days and 28 days were significantly higher than those of the control group (P <0.05). The 28-day inefficiency rate of the control group was significantly higher than that of the study group (P <0.05). Conclusion Itraconazole combined with miconazole nitrate suppository has the better clinical effect and lower recurrence rate than the single use of miconazole nitrate suppository, which is worthy of clinical application.