大多数急性心肌梗死(AMI)患者能并发明显的情绪性疼痛应激反应,这种应激反应最终能引起心肌坏死区扩大并导致左心室功能不全恶化。所以对 AMI 患者及时而有效地缓解疼痛特别重要。但传统的止痛法(如皮下、肌肉或静注吗啡)不仅有时达不到有效的止痛效果,还可能引起呼吸和/或心血管方面的合并症。近年的研究发现,硬膜外止痛法对 AMI 患者不仅有显著地缓解疼痛效果,而且有抗心肌缺血和改善左心室功能等作用。本文报告作者关于硬膜外止痛法对 AMI 的临床疗效进行研究的结果。对象与方法共选择76例大灶性 AMI 为研究对象,全部患者均为首次发生心肌梗死并均在出现心绞痛后12h内入院。为便于观察硬膜外止痛法的疗效将76例患者分成 Most patients with acute myocardial infarction (AMI) can develop significant emotional pain-related stress reactions that eventually cause an enlargement of the myocardial necrosis and worsening of left ventricular dysfunction. Therefore, timely and effective relief of pain in patients with AMI is particularly important. However, traditional analgesic methods (such as subcutaneous, intramuscular or intravenous morphine) sometimes fail to achieve effective analgesic effects and may cause respiratory and / or cardiovascular comorbidities. In recent years, the study found that epidural analgesia in AMI patients not only significantly relieve pain effect, but also anti-myocardial ischemia and improve left ventricular function. This article reports the authors’ findings regarding the clinical efficacy of epidural analgesia for AMI. Subjects and Methods A total of 76 cases of large focal AMI were selected as the study subjects, all patients were the first to have myocardial infarction and were admitted within 12 hours after angina pectoris. In order to facilitate the observation of the efficacy of epidural analgesia, 76 patients were divided into