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目的:研究不同剂量促性腺激素释放激素激动剂(Gn Rh-a)对子宫腺肌症患者术后恢复的影响。方法:纳入70例接受腹腔镜子宫腺肌症病灶剔除术的患者作为研究对象,随机抽签分为两组,各35例。两组均在术后月经来潮第3d给予肌注Gn Rh-a3.75mg,观察组后5次给药剂量减半,对照组仍给予3.75mg/次,两组给药间隔时间28d,均给药6次。比较两组术后血清激素水平、妊娠、复发及不良反应发生情况。结果:两组治疗结束时LH、FSH、E2及CA125较治疗前均显著降低(P<0.05),两组治疗结束时各指标均无显著性差异(P>0.05)。观察组不良反应发生率较对照组显著降低(P<0.05)。观察组妊娠率和复发率分别为65.71%和11.43%。对照组分别为54.29%和5.71%,两组妊娠成功率和复发率均无显著性差异(P>0.05)。结论:子宫腺肌症患者病灶剔除术后给予小剂量Gn Rh-a能显著改善患者生育能力,获得较低的复发率,且安全性高,值得临床推广。
Objective: To study the effects of different doses of gonadotropin-releasing hormone agonist (Gn Rh-a) on postoperative recovery in patients with adenomyosis. Methods: A total of 70 patients undergoing laparoscopic resection of adenomyosis were enrolled in this study. Random sampling was divided into two groups of 35 patients. Gn Rh-a3.75mg was intramuscularly injected in the third day after menstrual cramps in the two groups, and the dose of the Gn Rh-a in the observation group was halved in the fifth dose, while the control group was still given 3.75mg / time, the interval between two administrations was 28d Medicine 6 times. Serum hormone levels, pregnancy, recurrence and adverse reactions were compared between the two groups. Results: The levels of LH, FSH, E2 and CA125 in both groups were significantly lower than those before treatment (P <0.05). There was no significant difference between the two groups at the end of treatment (P> 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05). The pregnancy rate and recurrence rate in observation group were 65.71% and 11.43% respectively. The control group were 54.29% and 5.71% respectively. There was no significant difference in pregnancy success rate and recurrence rate between the two groups (P> 0.05). Conclusions: Gn Rh-a given in patients with adenomyosis after focal evisceration can significantly improve fertility, lower recurrence rate and high safety. It is worthy of clinical promotion.