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目的研究长链非编码RNA CRNDE(lncRNA CRNDE)在结直肠癌组织中的表达及其临床意义。方法收集潍坊医学院附属医院2016年9月~2017年3月60例结直肠癌组织及癌旁组织标本,采用Real-time PCR法检测组织标本中lncRNA CRNDE的表达,分析其表达的临床意义。结果 lncRNA CRNDE在结直肠癌组织标本中的表达较癌旁正常组织明显增高(P<0.01),lncRNA CRNDE的高表达与肿瘤大小、区域淋巴结转移及远处转移显著相关(P均<0.01),而与患者的性别、年龄、肿瘤部位无关(P均>0.05)。结论 lncRNA CRNDE表达水平在结直肠癌组织标本中显著升高。lncRNA CRNDE可作为潜在的结直肠癌诊断的分子标志物。
Objective To study the expression of long chain noncoding RNA (CRnE) CRNDE in colorectal cancer and its clinical significance. Methods Sixty colorectal cancer tissues and para-cancerous tissue specimens from Weifang Medical College Hospital from September 2016 to March 2017 were collected. Real-time PCR was used to detect the expression of lncRNA CRNDE and its clinical significance was analyzed. Results The expression of lncRNA CRNDE in colorectal cancer tissues was significantly higher than that in normal tissues (P <0.01). The high expression of lncRNA CRNDE was significantly associated with tumor size, regional lymph node metastasis and distant metastasis (all P <0.01) But not with the patient’s gender, age, tumor site (P> 0.05). Conclusion The expression of lncRNA CRNDE is significantly increased in colorectal cancer tissues. lncRNA CRNDE can be used as a potential molecular marker for the diagnosis of colorectal cancer.