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目的本研究旨在用非线性分析方法,探讨-6°头低位卧床试验对心血管调控机制的影响,并将对照组和中药组进行比较。方法 14名男性健康志愿者随机分入对照组和中药组,进行60d的头低位卧床试验。在试验前、中、后,运用非线性分析技术对心率变异、血压变异进行测试。结果志愿者心率水平在卧床开始后的前21d保持稳定,但从卧床试验的第41天起显著升高,且在卧床结束后亦未恢复至正常;趋向波动指数(DFAα1)于卧床试验开始后的第2天出现明显升高,且维持升高状态至试验结束后的第12天;混沌指数(chaos)在卧床过程中明显下降。卧床试验过程中组间对比发现:对照组心率变异的1/f以及血压变异的SDNN、LF/HF、DFAα1和1/f明显高于中药组,并且心率变异的DFAα2和血压变异的HF明显降低。结论在卧床试验后期机体出现迷走神经张力下降,迷走交感平衡升高;而中药可以减轻模拟失重对心血管系统的影响。
Objective This study aimed to investigate the effect of -6 ° head-down bed rest on cardiovascular regulation using non-linear analysis, and compare the control group with the traditional Chinese medicine group. Methods Fourteen male healthy volunteers were randomly divided into control group and traditional Chinese medicine group for 60 days. Before, during, after, the use of non-linear analysis of heart rate variability, blood pressure variations were tested. Results The volunteers’ heart rate remained stable in the first 21 days after bed rest, but rose significantly from the 41st day of bed-ridden test and did not return to normal after the end of bed rest. The trend fluctuation index (DFAα1) On the 2nd day, and maintained on the 12th day after the end of the experiment. The chaos decreased obviously in the bedridden period. During bed-trial, comparison between groups showed that 1 / f of heart rate variation and SDNN, LF / HF, DFAα1 and 1 / f of blood pressure variation in control group were significantly higher than those in Chinese medicine group, and heart rate variability DFAα2 and blood pressure variation HF were significantly decreased . Conclusion In the late bedside test, the vagus nerve tension is decreased and vagal sympathetic balance is increased. However, traditional Chinese medicine can reduce the impact of simulated weightlessness on the cardiovascular system.