本研究有三个目的:1)比较吡喹酮治疗前后曼氏血吸虫感染儿童对SEA中不同的抗原组分的免疫应答状况,对曼氏血吸虫虫卵中与血吸虫活力相关的特异性抗原或表位进行鉴定;2)采用治疗前对SEA蛋白不同识别方式的验证评估对儿童化疗的成败;3)比较两种不同流行区人群治疗反应状况,以估计他们对化疗反应的均一性。 从委内瑞拉Caraballeda镇选16名感染儿童作治疗前后观察。该地区经灭螺和加强 This study has three purposes: 1) To compare the immune response to different antigenic components of SEA in children infected with Schistosoma mansoni before and after treatment with praziquantel, to compare the specific antigen or epitope associated with the activity of schistosome in Schistosoma mansoni 2) assessing the success or failure of chemotherapies in children by validating different ways of identifying SEA proteins prior to treatment; and 3) comparing treatment response status among populations in two different endemic areas to assess their response to chemotherapy. Sixteen infected children were selected for observation before and after treatment from Caraballeda, Venezuela. The area has been cut off and strengthened