论文部分内容阅读
目的 建立儿童血清甘露聚糖凝集素 (MBL)水平正常值参考范围 ,了解血清MBL低水平与反复呼吸道感染的关系。方法 用ELISA方法检测重庆地区 91例新生婴儿脐血MBL水平 ,2 6 3例学龄前儿童、1 6例成人血清MBL水平 ,并对学龄前各年龄组血清低MBL水平的儿童进行反复呼吸道感染的病史回顾。结果 新生儿脐血MBL水平为 ( 1 .71± 1 .6 0 ) μg/ml,成人外周血 ( 2 .2 6± 1 .56 ) μg/ml,两组比较差异无统计学意义 (P >0 .0 5) ,学龄前各年龄组MBL水平分别为 ( 3.1 6±2 .0 0 ) μg/ml、( 3.1 9± 1 .88) μg/ml、( 3.30± 2 .0 5) μg/ml、( 3.6 9± 2 .2 2 ) μg/ml、( 2 .80± 1 .38) μg/ml,与新生儿比较明显增高 (P <0 .0 0 5) ,但学龄前期各组间比较差异无统计学意义 (P >0 .0 5) ;1 6例血清低MBL水平儿童中 7例在 3岁前出现反复呼吸道感染 ( 4 3.7% ) ,主要感染方式为上呼吸道感染 ,血清MBL水平低于 1 0 0ng/ml组与血清MBL水平在 1 0 0～ 2 0 0ng/ml的儿童比较反复呼吸道感染频率有增多趋势。结论 新生儿期MBL水平可达成人水平 ,但明显低于学龄前各年龄组儿童 ,学龄前儿童组间比较没有显著差异 ;低血清MBL水平儿童在免疫脆弱阶段存在反复呼吸道感染的易患倾向 ,血清MBL水平下降时 ,呼吸道感染频率有增?
Objective To establish a normal range of reference value of serum MBL in children and to understand the relationship between serum MBL low level and recurrent respiratory tract infection. Methods Serum levels of MBL were detected in 91 newborn infants in Chongqing, 263 cases of pre-school children, and 16 cases of adult serum by ELISA. Repeated respiratory infections were also detected in children with low serum MBL levels before school age Medical history review. Results The neonatal cord blood MBL level was (1.71 ± 1.60) μg / ml, adult peripheral blood (2.26 ± 1.56) μg / ml, there was no significant difference between the two groups (P> 0.05). The pre-school age MBL levels were (3.1 6 ± 2.0) μg / ml, (3.1 9 ± 1.88) μg / ml and (3.30 ± 2.05) μg / ml, (3.6 9 ± 2.22) μg / ml and (2.80 ± 1.38) μg / ml respectively, which were significantly higher than those of neonates (P <0.05) There was no significant difference between the two groups (P> 0.05). Seven of 16 children with low serum MBL had recurrent respiratory tract infection before the age of 3 (4. 3.7%). The main infection patterns were upper respiratory tract infection, serum MBL There was an increasing trend of recurrent respiratory infections in children with a level below 100 ng / ml and serum MBL levels between 100 and 2.0 ng / ml. Conclusions The level of MBL in the neonatal period can reach the adult level, but it is significantly lower than that of preschool children of all age groups. There is no significant difference between the preschool children group; children with low serum MBL level have the predisposition to recurrent respiratory tract infection in the fragile immune stage, Serum MBL levels decline, the frequency of respiratory infections have increased?