帕金森病(Parkinson’s disease,PD)是一种常见的中枢神经系统变性疾病,平均发病年龄为60岁左右。最主要的病理改变是中脑黑质多巴胺能神经元的变性死亡,由此而引起纹状体多巴胺(DA)含量显著性减少。临床主要表现为静止性震颤、运动迟缓、肌强直和姿势步态障碍及其他非运动 Parkinson’s disease (PD) is a common central nervous system degenerative disease with an average age of onset of about 60 years. The main pathological change is the degeneration and death of dopaminergic neurons in the substantia nigra, resulting in a significant reduction of striatum dopamine (DA) content. The main clinical manifestations of resting tremor, bradykinesia, muscle rigidity and posture gait disorders and other non-exercise