目的:探讨祖卡木颗粒和罂粟壳提取液临床剂量和疗程与超临床剂量和疗程使用对小鼠行为学潜在的不期望出现的对生理功能的不良影响,即其对中枢神经系统的影响,确定其可能关系到人用药安全性的非期望药理作用,本研究通过神经药理学方法阐明祖卡木颗粒长期反复使用是否能产生药物依赖性,以及药物依赖作用及可能的作用机制,为其临床应用提供实验数据和确保人民用药安全有效以及提供祖卡木颗粒药物安全评价。方法(1)不同浓度的祖
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