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玉女煎以10g/kg、20g/kg给小鼠连续灌胃给药7d,观察其对实验性糖尿病小鼠的降血糖作用。结果显示:该药对正常小鼠血糖无明显影响;对由四氧嘧啶所致的糖尿病小鼠有明显的治疗和预防作用;并显著对抗肾上腺素引起的小鼠血糖升高。此外,该药给小鼠灌胃,其最大耐受量为275g/kg,相当于成人日用量的112倍,显示该药临床用药较安全。
Jade decoction was administered to the mice by gavage at 10g/kg and 20g/kg for 7 days, and its hypoglycemic effect on experimental diabetic mice was observed. The results showed that the drug had no significant effect on blood glucose in normal mice; it had obvious therapeutic and preventive effects on diabetic mice caused by alloxan; and it significantly inhibited epinephrine-induced elevated blood glucose in mice. In addition, the drug was given to the mice by gavage, and the maximum tolerated dose was 275 g/kg, which was equivalent to 112 times the adult daily dose, indicating that the drug was clinically safer.