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脑钠肽(BNP)和氨基末端脑钠尿肽原(NT-proBNP)是儿童心血管疾病中的重要指标,其水平与儿童的年龄及性别相关。目前的研究表明,BNP与NT-proBNP对于心力衰竭(心衰)具有较高的诊断价值,特异性和敏感性均较高,有助于心衰与单纯性肺源性因素所致急性呼吸困难的鉴别。另外,在肺动脉高压、心肌病和川崎病的患儿中,BNP与NT-proBNP均可以有助于判断病情和指导治疗。目前的局限在于研究样本量相对偏小,检测方法及正常值范围未完全统一。
Brain natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) are important markers of cardiovascular disease in children, and their levels are related to children’s age and gender. The current study shows that BNP and NT-proBNP have high diagnostic value, high specificity and sensitivity for heart failure (heart failure), and are helpful for acute dyspnea caused by heart failure and simple pulmonary factors The identification. In addition, in patients with pulmonary hypertension, cardiomyopathy and Kawasaki disease, both BNP and NT-proBNP can help determine the condition and guide the treatment. The current limitation is that the sample size is relatively small, and the detection methods and normal range of values are not completely unified.