论文部分内容阅读
目的:基于一贯性高血糖症能导致胰岛素抵抗的假说,我们研究了高糖低脂饮食导致的非胰岛素依赖糖尿病大鼠的生理功能和组织学改变。方法:取正常新西兰兔24只,随机分为正常组、糖尿病(DM)组、糖尿病骨钙素干预(DM+OCGY)组。采用高唐低脂饮食喂养新西兰兔,建立非胰岛素依赖糖尿病模型。建立模型后,DM+OCGY组腹腔注射骨钙素(2.5 mg/kg·d),DM组腹腔注射相等量生理盐水。一个月后处死新西兰兔。用HE染色方法检测新西兰兔胰腺形态改变。结果:高糖低脂饮食能有效引起新西兰兔血糖的升高,尿糖阳性,HE染色表明胰腺细胞发生相应改变,DM+OCGY组空腹血糖的浓度明显降低,能逆转胰腺的相关改变。结论:高糖低脂饮食能诱导非胰岛素依赖糖尿病的发生,骨钙素对非胰岛素依赖型糖尿病血糖浓度有一定的调节作用。
OBJECTIVE: Based on the hypothesis that consistent hyperglycemia leads to insulin resistance, we investigated the physiological function and histological changes in non-insulin dependent diabetic rats caused by high-sugar, low-fat diet. Methods: Totally 24 New Zealand rabbits were randomly divided into normal group, DM group and DM + OCGY group. New Zealand rabbits were fed with low fat diet of Gaotang to establish non-insulin-dependent diabetic model. After establishing the model, DM + OCGY group was given intraperitoneal injection of osteocalcin (2.5 mg / kg · d), and DM group was injected with normal saline by intraperitoneal injection. New Zealand rabbit executed a month later. The morphological changes of pancreas in New Zealand rabbits were detected by HE staining. Results: High glucose and low fat diet could effectively raise the level of blood glucose in New Zealand rabbits. Positive urine sugar showed that the number of fasting blood glucose in DM + OCGY group was significantly lower than that in DM + OCGY group, and the changes of pancreas could be reversed. CONCLUSION: High-sugar and low-fat diet can induce non-insulin-dependent diabetes mellitus, and osteocalcin has a certain regulatory effect on non-insulin-dependent diabetes mellitus.