志贺毒素(Stx)是肠出血性大肠杆菌的毒力因子,其毒性取决于毒素的B亚单位与宿主细胞上糖配体的结合。抗B亚单位抗体,特别是粘膜表面分泌的IgA应有助于宿主的防卫。但B亚单位的免疫原性较弱,且受主要组织相容性复合体(MHC)的严格限制。日本静冈大学药学院Imai制备了重组型Stx B Shiga toxin (Stx) is a virulence factor of enterohemorrhagic Escherichia coli whose toxicity depends on the binding of the toxin B subunit to the sugar ligand on the host cell. Anti-B subunit antibodies, especially IgA secreted on the mucosal surface, should help host defense. However, the B subunit is less immunogenic and is severely limited by the major histocompatibility complex (MHC). Imai, Japan’s Shizuoka University School of Pharmacy, produced recombinant Stx B