论文部分内容阅读
目的：观察小剂量高渗氯化钠（ＨＳ）复苏失血性休克时红细胞（ＲＢＣ）能量代谢的变化。方法：２０只健康家兔被随机分为三组，（甲组）正常血容量输注ＨＳ组；（乙组）休克输注ＮＳ复苏组；（丙组）休克输注ＨＳ复苏组。以ＲＢＣ内ＡＴＰ和２，３－ＤＰＧ水平作为ＲＢＣ能量代谢的指标。结果：休克后ＲＢＣ内ＡＴＰ和２，３－ＤＰＧ水平显著下降，应用小剂量ＨＳ复苏后两项指标均有所回升，在输注后１２０分钟有显著增高。结论：应用小剂量ＨＳ可使失血性休克后的ＲＢＣ能量代谢状态发生明显改善，这可能是促进ＨＳ有效复苏休克的重要因素。
Objective: To observe the changes of energy metabolism of erythrocytes (RBC) during hemorrhagic shock with low dose of hypertonic sodium chloride (HS). Methods: Twenty healthy rabbits were randomly divided into three groups: (Group A) normal blood volume infusion of HS group; (Group B) shock infusion of NS resuscitation group; (Group C) shock infusion of HS resuscitation group. RBC ATP and 2,3-DPG levels as RBC energy metabolism indicators. Results: The levels of ATP and 2,3-DPG in RBC decreased significantly after shock, and both indexes recovered after low-dose HS resuscitation and increased significantly 120 minutes after infusion. Conclusion: The application of low-dose HS can significantly improve the energy metabolism state of RBC after hemorrhagic shock, which may be an important factor to promote HS effective resuscitation shock.