X线修复交叉互补基因1(XRCC1)是一种重要的DNA修复基因,参与DNA单链断裂和碱基损伤修复,其编码的蛋白质在碱基修复过程中是不可缺少的。该基因的多态性会导致相应的氨基酸改变,从而影响DNA修复,可能引起肿瘤的易感性。XRCC1基因多态性与吸烟交互作用对肺癌易感性的关系仍然存在争论,其相关性需进一步深入研究。 XRCC1 (XRCC1) is an important DNA repair gene involved in DNA single strand breaks and base damage repair. The protein encoded by XRCC1 is indispensable in the process of base repair. Polymorphism of the gene will lead to the corresponding amino acid changes, thus affecting DNA repair, may cause tumor susceptibility. The relationship between XRCC1 gene polymorphism and cigarette smoking on lung cancer susceptibility remains controversial, and its relevance needs to be further studied.