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目的:探讨血管紧张素Ⅱ受体阻断剂(厄贝沙坦)/噻嗪类利尿剂(氢氯噻嗪)联合用药治疗高血压的临床疗效。方法:选择高血压患者90例,随机分为厄贝沙坦组、氢氯噻嗪组和联合治疗组三组,分别治疗2个月后评价患者血压控制效果及不良反应。结果:治疗2个月后,三组患者的血压(收缩压和舒张压均)均有下降,但联合治疗组的血压降低程度大于其他二组(P<0.05),且联合治疗组不良反应少于其他二组,联合用药组的疗效与其他二组相比差异具有统计学意义(P<0.05)。结论:合理搭配药物治疗效果优于单一药物,联合用药疗效更好,不良反应更少,可作为医院合理用药的一个发展方向。
Objective: To investigate the clinical effect of combination therapy of angiotensin Ⅱ receptor blocker (irbesartan) and thiazide diuretic (hydrochlorothiazide) on hypertension. Methods: Ninety patients with hypertension were randomly divided into irbesartan group, hydrochlorothiazide group and combination therapy group. The blood pressure control effect and adverse reactions were evaluated after two months treatment respectively. Results: After 2 months of treatment, the blood pressure (systolic and diastolic blood pressure) decreased in all three groups, but the reduction of blood pressure in the combined treatment group was greater than that in the other two groups (P <0.05). The adverse reactions in the combined treatment group were less In the other two groups, the difference between the two groups was statistically significant (P <0.05). Conclusion: The rational treatment with drugs is better than single drug, combined therapy is more effective and less adverse reactions, which can be used as a rational development of the hospital.