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将妊娠期大鼠按体重随机分成5组,分别设3个3,4-双(4’-氨基呋咱基-3’)氧化呋咱(DATF)剂量组(625、1 250、2 500 mg/kg)、阴性对照组(3%淀粉溶液)和阳性对照组(环磷酰胺12 mg/kg)。于妊娠敏感期(第5~19天)连续给药,第20天处死孕鼠,取出胎鼠,记录总着床数、活胎数、死胎数、吸收胎数等,称子宫连胎总质量、活胎质量,测量胎鼠身长,检查胎鼠外观、内脏和骨骼有无畸形。结果显示,与阴性对照组比较,DATF各剂量组孕鼠体重、活胎数、死胎数、吸收胎数、胎鼠体重、平均身长等差异均无统计学意义(P>0.05),未见外观、内脏和骨骼出现明显畸形。提示,在本实验条件下未见DATF有明显的大鼠母体毒性和胎鼠致畸性。
Gestational rats were randomly divided into 5 groups according to body weight. Three DATF dosage groups, 3,4-bis (4’-aminofurazan-3 ’) (625,1 250,2 500 mg / kg), negative control group (3% starch solution) and positive control group (cyclophosphamide 12 mg / kg). The pregnant rats were sacrificed on the 20th day, fetus was removed, the total number of implants recorded, the number of live fetuses, the number of stillbirths, the number of absorbed fetuses, etc., said the total mass of the uterus with continuous tire , The quality of live births, fetal body length measurement, check the appearance of fetal rats, visceral and skeletal without deformity. The results showed that, compared with the negative control group, there was no significant difference in body weight, number of live births, number of stillbirths, number of fetuses fetus, body weight of fetuses and average length of pregnant rats in each dose group of DATF (P> 0.05) , Visceral and skeletal obvious deformity. Tip, no DATF in this experimental conditions have significant maternal toxicity and fetal teratogenicity.