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目的 :观察人精浆中各种微量蛋白与男性生殖能力之间的关系。方法 :应用放射免疫分析(RIA) ,对 2 2例生育者和 1 2 5例不育者精浆中的白蛋白 (Alb)、β2 -微球蛋白 (β2 -m)、α1 -微球蛋白 (α1 -m)、TH糖蛋白 (THP)、免疫球蛋白G(IgG)、分泌型免疫球蛋白A(SIgA)、铁蛋白 (Fer)等进行了检测。 结果 :不育症组精浆中Alb、β2 -m、α1 -m、THP、IgG、SIgA均明显低于生育组 ,尤其是Alb、β2 -m、α1 -m、IgG、SIgA在生育组与不育组之间均存在显著性差异 (p <0 0 5或p <0 0 1 ) ;不育症组精浆中Fer含量明显高于生育组 (p <0 0 1 )。结论 :精浆中 β2 -m、Alb、Fer含量与精液中的精子密度均存在密切正相关。对精浆SIgA和IgG含量的观察 ,可以判断男性生殖系统局部的免疫功能状态。测定精浆中Alb、β2 -m、Fer、SIgA和IgG等微量蛋白的含量可以帮助判断男性不育者的状态 ,指导临床对其进行有效的治疗。
Objective: To observe the relationship between various trace proteins in human seminal plasma and male reproductive capacity. Methods: The serum levels of Alb, β2 - microglobulin (β2 - m), α1 - microglobulin in seminal plasma of 22 infertile and 125 infertile women were detected by radioimmunoassay (RIA) (α1-m), TH glycoprotein (THP), immunoglobulin G (IgG), secreted immunoglobulin A (SIgA), ferritin (Fer) were detected. Results: The levels of Alb, β2-m, α1-m, THP, IgG and SIgA in seminal plasma of infertility group were significantly lower than that of the reproductive group, especially Alb, β2-m, There was significant difference between infertile groups (p <0.05 or p <0.01). The content of Fer in seminal plasma of infertile group was significantly higher than that of fertile group (p <0.01). Conclusion: The content of β2-m, Alb, Fer in seminal plasma is closely related to the sperm density in semen. Seminal plasma SIgA and IgG content of the observation, you can determine the male reproductive system local immune function status. Determination of seminal plasma Alb, β2-m, Fer, SIgA and IgG and other trace protein levels can help determine the status of male infertility, and guide the clinical treatment of its effective.