肺炎支原体(Mp)是儿童和青少年呼吸道感染的常见病原体,大环内酯类抗生素是治疗Mp感染的首选药物。以红霉素为代表的大环内酯类抗生素作用机制是通过抑制蛋白质的合成而发挥抗菌作用,即大环内酯类抗生素结合于核糖体50S亚基的转肽酶中心与肽输出通道狭窄之间的部分,通过机械性 Mycoplasma pneumoniae (Mp) is a common cause of respiratory tract infections in children and adolescents. Macrolide antibiotics are the first choice for the treatment of Mp infections. The macrolide antibiotics, represented by erythromycin, play an antibacterial effect by inhibiting the synthesis of the protein, namely, the macrolide antibiotic binds to the transpeptidase center of the 50S ribosomal subunit and narrows the output channel of the peptide The part between, through mechanical