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目的探讨脑囊虫病患者经吡喹酮治疗后,机体免疫应答的状态和对病程转归影响。方法35例脑囊虫病患者经吡喹酮治疗6个月后,对血清中IL-2、INF-γ、IL-5、IL-10、TNF-α、IL-12进行检测。结果治疗6个月后,Th1型细胞因子IL-2、IFN-γ、IL-12明显升高(P<0.01),Th2型细胞因子IL-5和IL-10在患者中检出率明显下降(P<0.01),TNF-α水平较治疗前显著下降(P<0.05)。治疗组对药物反应良好的患者,IL-2、IFN-γ、IL-12明显高于对药物反应不良者。结论脑囊虫病患者治疗后Th2型细胞因子反应减弱,而Th1型细胞因子反应增强,机体的保护性免疫应答已经开始恢复。
Objective To investigate the effect of praziquantel on immune response and prognosis of patients with cerebral cysticercosis. Methods Serum IL-2, INF-γ, IL-5, IL-10, TNF-α and IL-12 were detected in 35 patients with cerebral cysticercosis after praziquantel treatment for 6 months. Results Six months after treatment, the levels of Th1 cytokines IL-2, IFN-γ and IL-12 were significantly increased (P <0.01). The detection rates of Th2 cytokines IL-5 and IL-10 in patients were significantly decreased (P <0.01). The level of TNF-α was significantly lower than that before treatment (P <0.05). The treatment group responded well to drugs, IL-2, IFN-γ, IL-12 was significantly higher than those who did not respond to drugs. Conclusion The treatment of patients with cerebral cysticercosis Th2-type cytokine response weakened, and Th1-type cytokine response increased, the body’s protective immune response has begun to recover.