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总合草苔虫Bugula neritina是一种海洋底栖动物,广泛分布于世界各海域。自1968年美国亚利桑那州立大学癌研究所首次发现它的抗癌活性以来,以釜野德明为中心的 Pettit研究小组已从中分离得到18个大环内酯类化合物(bryostatinl～18)。其中bryostatin 1和bryostatin 4的抗癌活性最强。经美国国立癌研究院(NCI)的生物鉴定,已投入临床试验,是极有希望的新型抗癌药物。本文对bryostatin类化合物的化学结构、提取分离方法及主要生物活性加以综述。
Bugula neritina is a marine benthic animal, widely distributed in the world’s waters. Since its first anticancer activity was discovered in the Cancer Institute of Arizona State University in 1968, Pettit’s research group centered on Demeter in Ibuya has isolated 18 macrolide compounds (bryostatinl-18). Among them, bryostatin 1 and bryostatin 4 have the strongest anticancer activity. The biological identification of the National Cancer Institute (NCI) has been put into clinical trials and is a promising new anti-cancer drug. This article reviews the chemical structure, extraction and separation methods and main biological activities of bryostatin compounds.