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[目的]探讨短时期内苯对鞋厂工人机体免疫系统的影响。[方法]采用单克隆抗体APAAP法,对50例鞋厂工人进行T淋巴细胞亚群检测。[结果]与健康非苯接触人员相比较,短期苯接触工人T淋巴细胞亚群CD4值+无明显变化,差异无统计学意义(P﹥0.05);而CD3及CD8值显著增加,差异有统计学意义(P﹤0.01);CD4/CD8比值++++显著降低,差异有统计学意义(P﹤0.01)。短期苯接触工人在工龄、车间、性别方面相互比较时,T淋巴细胞亚群CD3、+CD4、CD8及CD4/CD8比值均无明显变化,差异无统计学意义(P﹥0.05);而分别与对照组相比较时短期苯接触工人T++++淋巴细胞亚群只有CD4值无明显变化,差异无统计学意义(P﹥0.05);CD3及CD8值均显著增加,差异有统计学意义(P+++﹤0.01);CD4/CD8比值均显著降低,差异有统计学意义(P﹤0.01)。这与总结果保持一致。++[结论]短期接触苯对T淋巴细胞亚群的主要影响是引起CD8+T细胞增加,使机体细胞的免疫紊乱。
[Objective] To investigate the effect of benzene on the body’s immune system in shoe factories in a short period of time. [Methods] Monoclonal antibody APAAP method was used to detect T lymphocyte subsets in 50 cases of shoe factory workers. [Results] There was no significant difference in CD4 + value of T lymphocyte subsets between short-term benzene exposure workers and non-benzene exposure workers (P> 0.05), while the values of CD3 and CD8 were significantly increased (P <0.01). The ratio of CD4 / CD8 was significantly decreased (P <0.01). There was no significant difference in the ratio of CD3, CD4, CD8 and CD4 / CD8 of T lymphocyte subsets between short-term benzene exposed workers in terms of length of service, workshop and gender (P> 0.05) There was no significant difference in CD4 (superscript +) T lymphocyte subpopulation in short-term benzene exposure workers (P> 0.05), while the CD3 and CD8 values were significantly increased (P +++ <0.01) ; CD4 / CD8 ratio were significantly lower, the difference was statistically significant (P <0.01). This is consistent with the overall result. ++ [Conclusion] The main effect of short-term exposure to benzene on T lymphocyte subsets is to cause the increase of CD8 + T cells and the disorder of immune cells in the body.