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继发性甲状旁腺功能亢进(SHPT)是慢性肾脏病(CKD)常见的并发症之一。随着肾小球滤过率的下降,循环中甲状旁腺激素(PTH)水平逐渐升高。CKD患者的PTH分泌和代谢紊乱,以及靶器官对PTH反应性降低在SHPT的发生发展中发挥重要作用,近年来其相关机制也得到进一步阐明。由于CKD患者PTH代谢和功能异常,PTH作为CKD预后判断标志物的价值仍存在争议。本文将对CKD患者存在的PTH代谢异常及其可能机制进行综述。
Secondary hyperparathyroidism (SHPT) is one of the common complications of chronic kidney disease (CKD). With the glomerular filtration rate decreased, circulating levels of parathyroid hormone (PTH) gradually increased. PTH secretion in patients with CKD and metabolic disorders, as well as target organs to reduce PTH responsiveness plays an important role in the occurrence and development of SHPT, and its related mechanisms have been further clarified in recent years. Because of PTH metabolism and dysfunction in patients with CKD, the value of PTH as a marker of CKD prognosis is still controversial. This article will be CKD patients with abnormal PTH metabolism and its possible mechanism are reviewed.