多囊卵巢综合征(polycystic ovary syndrome,PCOS)是以生殖功能障碍和糖代谢异常并存的内分泌紊乱综合征,其主要表现为胰岛素抵抗、高雄激素血症及肥胖,远期易并发2型糖尿病、心血管疾病、代谢综合征等。内酯素(vis-fatin)是新近发现的一种脂肪细胞因子,可以结合并激活胰岛素受体,发挥类胰岛素样作用,其与肥胖、糖尿病、PCOS等疾病密切相关。就内酯素与PCOS相关性的研究现状综述。 Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by reproductive dysfunction and abnormal glucose metabolism. Its main manifestations are insulin resistance, hyperandrogenism and obesity, long-term complicated with type 2 diabetes mellitus, Cardiovascular disease, metabolic syndrome and so on. Vis-fatin, a recently discovered adipocytokines, binds to and activates insulin receptors and acts like insulin-like, which is closely related to diseases such as obesity, diabetes and PCOS. A review on the research status of the correlation between lactone and PCOS.