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将50例糖尿病肾病Ⅲ期患者随分为两组:观察组(25例)患者给予硫辛酸联合依那普利治疗;对照组(25例)患者给予依那普利治疗。两组患者均有效控制血糖,空腹血糖(FBS)<8mmol/L、餐后2小时血糖(PBS)<10mmol/L。疗程2周,观察比较两组患者在治疗前后血肌酐(CR)、尿白蛋白排出量及尿白蛋白排泄率(UAER)。结果观察组的尿白蛋白排出量、UAER的水平低于对照组,两者的差异具有明显的统计学意义(P<0.05);两组患者的血肌酐水平差异无统计学意义(P>0.05)。结论硫辛酸联合依那普利,比单用依那普利能更有效地控制早期糖尿病肾病的蛋白尿。
Fifty patients with stage Ⅲ diabetic nephropathy were divided into two groups: observation group (25 cases) were given lipoic acid combined with enalapril treatment; control group (25 cases) were given enalapril treatment. Both groups were effective in controlling blood glucose, fasting blood glucose (FBS) <8mmol / L, 2 hours postprandial blood glucose (PBS) <10mmol / L. The course of treatment was 2 weeks. The levels of serum creatinine (CR), urinary albumin and urinary albumin excretion (UAER) in two groups were observed before and after treatment. Results The urinary albumin excretion and the level of UAER in the observation group were lower than those in the control group, with significant difference (P <0.05). There was no significant difference in serum creatinine between the two groups (P> 0.05 ). Conclusions Lipoic acid plus enalapril is more effective in controlling proteinuria in early diabetic nephropathy than enalapril alone.