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目的 分析p57kip2和Cyclin D1的表达在子宫内膜癌发生发展中的变化及其意义,为预测子宫内膜癌患者的预后提供重要依据.方法 选取76例子宫内膜癌,15例子宫内膜上皮内瘤变和10例子宫内膜增生性病变的患者资料,并对不同子宫内膜癌细胞进行培养,且对不同子宫内膜组织p57kip2和Cyclin D1的表达情况进行检测.结果 子宫内膜上皮内瘤变组织中p57kip2表达最高(46.67％),其次是子宫内膜癌(35.71％)与子宫内膜增生性病变(10.00％),其中p57kip2在子宫内膜上皮内瘤变、子宫内膜癌组织中的表达明显高于子宫内膜增生性病变(P＜0.05).Cyclin D1在子宫内膜癌中的表达最高(89.47％),其次是子宫内膜上皮内瘤变(53.33％)与子宫内膜增生性病变(10.00％),差异具有统计学意义(P＜0.05).结论 p57kip2和Cyclin D1可能参与子宫内膜癌的发生、发展过程,对两者进行联合检测,能够对预测子宫内膜癌患者的预后提供重要依据.“,”Objective To analyze the changes and significance of p57kip2 and Cyclin D1 expressions in occurrence and progression of endometrial cancer,provide an important basis for predicting prognosis.Methods The data of 76 cases with endometrial cancer,15 casewith endometrial intraepithelial neoplasia,and 10 cases with endometrial proliferative lesion was collected,different endometrial cancer cells were cultured,and the expression levels of p57kip2 and Cyclin D1 in different endometrial tissues were detected.Results The expression level of p57kip2 was the highest in endometrial intraepithelial neoplasia (46.67％),followed by endometrial cancer (35.71％) and endometrial proliferative lesion (10.00％).The expression levels of p57kip2 in endometrial intraepithelial neoplasia and endometrial cancer were statistically significantly higher than that in endometrial proliferative lesion (P＜0.05).The expression level of Cyclin D1 was the highest in endometrial cancer (89.47％),followed by endometrial intraepithelial neoplasia (53.33％) and endometrial proliferative lesion (10.00％),there were statistically significant differences (P＜0.05).Conclusion p57kip2 and Cyclin D1 may be involved in the occurrence and progression of endometrial cancer.Combined detection of p57kip2 and Cyclin D1 can predict the prognosis of patients with endometrial cancer and provide an important basis.