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氨苯砜在联合化疗中仍为主要药物。为在门诊治疗中监督病人规则用药,随时监测服药情况很必要。国内外已介绍过不少测定尿中氨苯砜及其代谢产物的方法,如高压液体层析法、薄层层析法、酶联法、指示剂显色法和指示药物间接测定法等。这些方法不是实验条件要求很高,操作较为复杂,就是试剂较昂贵不易购得,保存及携带不便,因
Dapsone is still a major drug in combination with chemotherapy. To monitor the patient’s regular medication in outpatient care, it is necessary to monitor the medication at any time. At home and abroad have introduced a number of methods for the determination of dapsone and its metabolites in urine, such as high pressure liquid chromatography, thin layer chromatography, enzyme linked method, indicator chromogenic assay and indirect drug indication. These methods are not demanding experimental conditions, the operation is more complex, is more expensive reagents is not easy to purchase, storage and carrying inconvenience, because