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受试者为62±7(47～71)岁的10例伴有充血性心力衰竭(NYHA Ⅲ～Ⅳ级)和心绞痛(除1例偶尔发作外,均为NYHA Ⅲ～Ⅳ级)的缺血性心脏病男性患者,各例均有心肌梗塞史,其中6例造影显示均为三支病变且不能手术治疗。入院后至少一周时间内,限制钠(2g/d)和水(1500～1800ml/d以下)的摄入量。停用扩血管药物至少3天且停用地高辛和利尿剂24小时,然后(于试验前日)进行水负荷试验:在40～75min内静脉注入5％葡萄糖溶液15ml/kg。随后5小时内测定血流动力学参数、(动脉血)神经体液因子和肾脏功能指标(包括每小时排尿一次备测)。试验首日,口服Nisoldipine 10mg(3例)后5小时内测定血流动力学参数;平均动脉压降低幅度 <10～20mmHg或者收缩压≥100mmHg者再服Nisoldipme 20mg(7例),随后5小时内测定血流动力学参数。次日起按上述剂量口服Nisoldipine
Subjects were ischemia of 62 patients (47-71) aged 10 with congestive heart failure (NYHA class III-IV) and angina (all NYHA class III-IV, except for one episode) Male patients with sexual heart disease, each case had a history of myocardial infarction, including 6 cases of angiography showed three lesions and can not be treated. Limit intake of sodium (2g / d) and water (1500-1800ml / d) for at least one week after admission. The vasodilator was discontinued for at least 3 days and digoxin and diuretics were discontinued for 24 hours prior to a water load test (on the day prior to the test): a 5% glucose solution 15 ml / kg was intravenously administered within 40-75 min. Hemodynamic parameters (arterial blood), neurohumoral factors and renal function parameters (including once per hour urination) were measured within 5 hours. On the first day of the experiment, hemodynamic parameters were measured within 5 hours after the oral administration of Nisoldipine 10 mg (n = 3); mean arterial pressure was reduced by <10-20 mmHg or systolic blood pressure> 100 mmHg, and then nisoldipme 20 mg (n = 7) Haemodynamic parameters were measured. The next day the above dose of oral Nisoldipine