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目的:考察注射用氨苄西林钠/舒巴坦钠与奥硝唑氯化钠注射液配伍的稳定性。方法:采用高效液相色谱法,考察配伍溶液在室温下放16h内不同时间点的含量变化,并观察其外观,测定其pH和不溶性微粒。结果:在室温(25℃)下,6 h内配伍溶液的外观、pH和药物的含量均无明显变化,不溶性微粒符合《中国药典》2005年版规定。结论:注射用氨苄西林钠/舒巴坦钠与奥硝唑氯化钠注射液配伍后6h内基本稳定。
Objective: To investigate the stability of compatibility between ampicillin sodium / sulbactam sodium and ornidazole sodium chloride injection. Methods: HPLC method was used to investigate the content change of compatibility solution at different time points within 16 h at room temperature. The appearance and the pH value and the insoluble particles were measured. Results: The appearance, pH and drug content of the compatibilized solution within 6 h at room temperature (25 ℃) showed no significant changes. The insoluble particles were in accordance with the 2005 edition of Chinese Pharmacopoeia. Conclusion: Ampicillin sodium / sulbactam sodium injection and ornidazole sodium chloride injection compatibility within 6h after the basic stability.