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目的:探讨静脉注射地尔硫和美托洛尔对快室率房颤治疗的有效性。方法:入选40例患者随机给予地尔硫或美托洛尔静脉注射,观察20 min。结果:20 min时地尔硫组和美托洛尔组总有效率分别为90%和80%,5 min后两组心室率均明显下降,20 min时平均心室率下降幅度分别为34.7%和28.6%;平均起效时间分别为(5.3±4.6)min和(9.4±6.4)min(P<0.05)。无严重不良反应。结论:地尔硫和美托洛尔对快室率房颤治疗安全有效,地尔硫控制心室率下降幅度更大,起效更快。
Objective: To investigate the efficacy of intravenous diltiazem and metoprolol in the treatment of fast atrial fibrillation. Methods: Forty patients were randomized to receive either diltiazem or metoprolol intravenously for 20 min. Results: The total effective rates of Diltiazem group and metoprolol group were 90% and 80% respectively at 20 minutes. After 5 minutes, the ventricular rate decreased significantly in both groups and the average ventricular rate decreased by 34.7% and 20% respectively 28.6%. The mean effective time was (5.3 ± 4.6) min and (9.4 ± 6.4) min respectively (P <0.05). No serious adverse reactions. CONCLUSION: Diltiazem and metoprolol are safe and effective in the treatment of AF with AF. Diltiazem reduces ventricular rate more rapidly and has a faster onset of AF.