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目的探究金双歧(双歧杆菌乳杆菌三联活菌)对住院小儿抗生素相关性腹泻(AAD)的预防作用。方法收集我院68例入院时无腹泻的感染性患儿,主要病种为支气管炎及支气管肺炎,随机分为研究组和对照组,每组34例,研究组患儿自开始使用抗生素起,同时口服金双歧(双歧杆菌乳杆菌三联活菌),直到停用抗生素后5d,0.5g/次,3次/d,对照组不采取任何干预措施,仅出现腹泻后给予金双歧口服治疗。比较两组AAD罹患率。结果研究组4例患儿发生AAD,罹患率12.1%。对照组11例患儿发生AAD,罹患率32.1%,两组患儿AAD发生率差异有统计学意义(P<0.05)。结论金双歧(双歧杆菌乳杆菌三联活菌)与抗生素同时应用,可降低小儿抗生素相关性腹泻的发生率,具有积极的临床预防作用,且简单、安全、无不良反应。
Objective To explore the preventive effect of Jinshuangqi (Lactobacillus bifidosis triplet) on antibiotic-associated diarrhea (AAD) in hospitalized children. Methods 68 cases of infective children admitted to our hospital without diarrhea were collected. The main diseases were bronchitis and bronchopneumonia. The patients were randomly divided into study group and control group, with 34 cases in each group. In the study group, children started antibiotics, At the same time oral gold bifidobacterium (Bifidobacterium Lactobacillus triple viable), until the antibiotics after stopping 5d, 0.5g / time, 3 times / d, the control group did not take any interventions, only after diarrhea given Jinshuangqi oral treatment. The incidence of AAD in both groups was compared. Results AAD occurred in 4 cases in study group, with an attack rate of 12.1%. AAD occurred in 11 children in the control group, with an attack rate of 32.1%. There was a significant difference in the incidence of AAD between the two groups (P <0.05). Conclusion Jinshuangqi (Bifidobacterium Lactobacillus triple viable) with antibiotics at the same time, can reduce the incidence of antibiotic-associated diarrhea in children, with a positive clinical preventive effect, and simple, safe and no adverse reactions.