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本文用脉冲伏安法在体测定麻醉大鼠纹体中二羟苯乙酸(DOPAC)的含量,并观察多巴胺受体拮抗剂氟哌啶醇(D_2/D_1)、氯丙嗪(D_2/D_1),舒必利(D_2)以及SCH23390(D_1)对纹体中DOPAC的影响。结果表明这些多巴胺受体拮抗剂均可使麻醉大鼠纹体中DOPAC含量增加,与基础DOPAC浓度(14±2μmol/L)相比,氟哌啶醇(0.5mg/kg s.c.),氯丙嗪(5mg/kgs.c.)、舒必利(5mg/kg s.c),SCH23390(1mg/kg s.c.)分别使DOPAC增加140％、102％、40％以及26％。从而证实不仅突触前D_2受体参与反馈调节DA的合成代谢,而且D_1受体也参与以上反馈调节机制,但D_2受体的调节作用较强。
In this study, dopamine antagonist haloperidol (D_2 / D_1) and chlorpromazine (D_2 / D_1) were determined in vivo by pulsed voltammetry. , Sulpiride (D_2) and SCH23390 (D_1) on DOPAC in the striatum. The results showed that these dopamine receptor antagonists can increase the content of DOPAC in the rat striatum compared with the basal DOPAC concentration (14 ± 2μmol / L), haloperidol (0.5mg / kg sc), chlorpromazine (5 mg / kg), Sulpiride (5 mg / kg sc), SCH23390 (1 mg / kg sc) increased DOPAC by 140%, 102%, 40% and 26%, respectively. Thus, it was confirmed that not only the presynaptic D 2 receptor is involved in the feedback regulation of DA anabolism, but also the D 1 receptor is involved in the above feedback regulation mechanism, but the D 2 receptor has a strong regulation effect.