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喉癌术后患者行颈部预防或根治性放疗时,因甲状腺暴露在照射区域,可能易受损伤。1990～1993年我们对33例喉癌患者术后施以放疗,现报告其临床资料,借以探讨放疗对甲状腺功能的影响。 1 资料和方法 33例喉癌患者中,女2例,男31例;年龄37～75岁。12例行全喉切除术,21例行部分喉切除术。其中8例同时接受改良或根治性颈廓清扫术,术中未切除甲状腺。术后用电子直线加速器10mV—X线放疗,剂量5000～6000cGy,每周5次,每次150～200cGy。18例随访半年,分别在放疗前和结束时以及随访中测定促甲状腺素释放因子(TSH)、四碘甲状腺素(T_4)、三碘甲状腺原氨酸(T_3)。
Patients with laryngeal cancer surgery after neck or radical radiotherapy, due to thyroid exposure in the irradiated area may be vulnerable to injury. From 1990 to 1993, 33 patients with laryngeal cancer were treated with radiotherapy, and clinical data were reported to explore the effect of radiotherapy on thyroid function. 1 Materials and Methods 33 cases of laryngeal cancer patients, 2 females, 31 males; aged 37 to 75 years. Total laryngectomy was performed in 12 cases and partial laryngectomy in 21 cases. Among them, 8 cases received both modified and radical neck dissection, and the thyroid was not removed during operation. Postoperative electron linear accelerator 10mV-X ray radiation dose 5000 ~ 6000cGy, 5 times a week, each time 150 ~ 200cGy. Totally 18 patients were followed up for six months. Thyrotropin releasing factor (TSH), tetrathiodothyronine (T_4) and triiodothyronine (T_3) were measured before radiotherapy and at the end of radiotherapy.