论文部分内容阅读
目的研究组织蛋白酶D(Cathepsin D,Cath-D)在恶性纤维组织细胞瘤(malignant fi-brous histiocytoma,MFH)组织中的蛋白表达情况,探讨其在MFH发生发展中的作用,为阐明MFH的发病机制提供科学依据。方法应用免疫组化方法检测65例MFH组织的Cath-D的蛋白表达情况,分析Cath-D蛋白表达率与临床病理特征之间的关系。结果Cath-D阳性表达主要定位于细胞浆。65例MFH组织中Cath-D蛋白阳性表达率为75.4%,I~II期Cath-D阳性率为60.0%,III~Ⅳ期Cath-D阳性率为88.6%,两者相比差异有显著性(P<0.01)。Cath-D的阳性表达率与病理分化程度和生存期显著相关(P<0.01)。结论Cath-D在MFH发生发展中起重要作用,是判断MFH侵袭、转移和预后的重要指标。
Objective To investigate the protein expression of Cathepsin D (Cath-D) in malignant fibrous histiocytoma (MFH) and its role in the development of MFH. To elucidate the pathogenesis of MFH, Mechanism to provide a scientific basis. Methods The protein expression of Cath-D in 65 cases of MFH was detected by immunohistochemistry. The relationship between the expression of Cath-D and clinicopathological features was analyzed. Results Cath-D positive expression mainly located in the cytoplasm. The positive expression rate of Cath-D protein in 75 cases of MFH was 75.4%, the positive rate of Cath-D in stage I-II was 60.0%, the positive rate of Cath-D in stage III-IV was 88.6%, the difference was significant (P <0.01). The positive expression rate of Cath-D was significantly correlated with the degree of pathological differentiation and survival (P <0.01). Conclusions Cath-D plays an important role in the occurrence and development of MFH and is an important index for judging the invasion, metastasis and prognosis of MFH.