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来自德国Gerard等人的研究[1]显示,卡培他滨方案术前放化疗联合奥沙利铂对于治疗局部进展期直肠癌,可降低肿瘤环周切缘阳性率,但在完全缓解率方面无明显益处,并显著增加了3～4级毒性反应。
The study by Gerard et al. [1] from Germany shows that capecitabine preoperative chemoradiation combined with oxaliplatin can reduce the positive rate of peri-tumor margins in the treatment of locally advanced rectal cancer, but in terms of complete remission rate No significant benefit, and significantly increased grade 3 to 4 toxicity.