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目的研究皮肌炎(dermatomyositis,DM)/多发性肌炎(polymyositis,PM)伴发恶性肿瘤的临床相关因素。方法回顾性分析我院8年来收治的22例DM/PM合并恶性肿瘤患者的临床相关资料,统计其合并恶性肿瘤的种类,与DM/PM发病的先后顺序及时间关系,并对患者进行年龄、性别及相关实验室检查结果的比较。结果DM/PM合并恶性肿瘤发生率为12.29%,肿瘤类型多样,以肺癌、胃癌、鼻咽癌等为主。40岁以上年龄组DM/PM患者合并恶性肿瘤的危险性高于40岁以下年龄组。伴发恶性肿瘤的DM/PM患者ESR、AST、CK、LDH及ALP的水平较不伴发恶性肿瘤患者高。结论年龄大于40岁,ESR、CK等升高为DM/PM伴发恶性肿瘤的临床相关因素。
Objective To study the clinically relevant factors of dermatomyositis (DM) / polymyositis (PM) associated with malignant tumor. Methods The clinical data of 22 patients with DM / PM with malignant tumor treated in our hospital over the past 8 years were retrospectively analyzed. The types of the malignant tumor with DM / PM and the sequence and time of DM / PM were analyzed retrospectively. The patients’ age, Comparison of gender and related laboratory test results. Results The incidence of DM / PM complicated with malignant tumor was 12.29%. The tumor types varied with lung cancer, gastric cancer and nasopharyngeal cancer. Patients with DM / PM in the age group of 40 and over have a higher risk of having a malignancy than those under 40 years of age. Patients with DM / PM accompanied with malignant tumors had higher levels of ESR, AST, CK, LDH and ALP than those without malignancy. Conclusions The age of more than 40 years old, ESR, CK and other elevated as DM / PM associated with malignant tumor clinical factors.