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目的:对比分析参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸治疗糖尿病周围神经病变的临床疗效。方法:研究对象来源于医院收治的116例糖尿病周围神经病变患者,根据掷骰子法将患者随机分为两组,每组58例。实验组患者采用参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸配合治疗,对照组患者使用甲钴胺及α-硫辛酸治疗。对比两组患者的不良反应发生率、周围神经平均传导速度及治疗后总有效率。结果:实验组患者的不良反应发生率(15.52%)明显优于对照组患者的(39.66%);实验组患者周围神经平均传导速度(60.25±0.26)m/s明显优于对照组的(50.96±0.68)m/s;实验组患者总有效率(98.27%)明显优于对照组的(91.38%),其差异在统计学上有意义(P<0.05)。结论:通过参芪降糖颗粒、银杏叶胶囊联合甲钴胺及α-硫辛酸联合治疗糖尿病周围神经病变后,能有效地降低不良反应发生概率、周围神经平均传导速度及治疗总有效率均有明显的提高,短期临床效果较好,但远期的临床效果仍然需要通过延长随访时间和加大样本量来进行证实。
OBJECTIVE: To compare and analyze the clinical effects of Shenqijiangtang granules, Ginkgo biloba capsules combined with mecobalamin and α-lipoic acid in the treatment of diabetic peripheral neuropathy. Methods: The subjects were from 116 hospitalized patients with diabetic peripheral neuropathy. According to the dice method, patients were randomly divided into two groups of 58 cases. Patients in the experimental group were treated with Shenqijiangtang granules, Ginkgo biloba capsules combined with mecobalamin and alpha-lipoic acid, while patients in the control group were treated with methylcobalamin and alpha-lipoic acid. The incidence of adverse reactions, mean peripheral nerve conduction velocity and total effective rate after treatment were compared between the two groups. Results: The incidence of adverse reactions in the experimental group was significantly higher than that in the control group (15.52% vs 39.66%). The mean peripheral nerve conduction velocity (60.25 ± 0.26) m / s in the experimental group was significantly higher than that in the control group (50.96% ± 0.68) m / s. The total effective rate (98.27%) in the experimental group was significantly higher than that in the control group (91.38%), the difference was statistically significant (P <0.05). Conclusion: The treatment of diabetic peripheral neuropathy with Shenqi Jiangtang Granule, Ginkgo biloba capsule combined with mecobalamin and α-lipoic acid can effectively reduce the incidence of adverse reactions, the average peripheral nerve conduction velocity and the total effective rate of treatment Significant improvement in short-term clinical effect is better, but the long-term clinical results still need to be confirmed by extending the follow-up time and increase the sample size.