Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseases.Nature provides us remedies for the treatment of various types of disorders ranging from simple ailments to complicated diseases.Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents.Flavonoids are one of the main active phytoconstituents found in fruits,vegetables,wines,tea and cocoa.Flavonoids exhibit various pharmacological activities such as antioxidant,anti-inflammatory,anti-allergic,antibacterial,oestrogenic,cytotoxic antitumoural,hepatoprotective,antithrombotic and antiviral activity.Diosmetin(3’,5,7-trihydroxy-4’-methoxyflavone),the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit.Although it is found in herbal medicines and plays an important role in the treatment of various ailments,only limited scientific researches have been conducted.The aim of this review is to collect all available scientific literature published on diosmetin and combine it into this paper.This review contains an overview of pharmacological activities,isolation techniques and analytical techniques for diosmetin.Thus,valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin. Plants have been used as a source for food material and natural remedies for the treatment of vast range of diseasess.Nature provides us remedies for the treatment of various types of disorders ranging from simple ailments to complicated diseases .Plants are known to possess different pharmacological activities due to the presence of various phytoconstituents. Flavonoids are one of the main active phytoconstituents found in fruits, vegetables, wines, tea and cocoa. Flavonoids exhibit various pharmacological activities such as antioxidant, anti-inflammatory, anti-allergic, antibacterial, oestrogenic, cytotoxic antitumoural, hepatoprotective, antithrombotic and antiviral activity. Diosmetin (3 ’, 5,7-trihydroxy-4’-methoxyflavone), the aglycone part of the flavonoid glycosides diosminsence naturally in citrus fruit. Although it is found in herbal medicines and plays an important role in the treatment of various ailments, only limited scientific researches have been conducted. The aim of this review is to col lect all available scientific literature published on diosmetin and combine it into this paper. This review contains an overview of pharmacological activities, isolation techniques and analytical techniques for diosmetin. Thus, valuable information provided in the present review will help researchers in developing alternative methods for the treatment of diseases from diosmetin.