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目的探讨围绝经妇女尿脱氧吡啶诺啉(Dpd)与骨密度的相关性,以评估尿Dpd筛查骨质疏松症(OP)高危人群的临床价值。方法以53例围绝经妇女为研究组,以300例绝经后OP及200例正常妇女为对照组,用酶联免疫吸附法(ELISA法)测定其3小时空腹晨尿Dpd及尿肌酐值。并用双能线吸收仪(DEXA)进行腰椎2～4(L2～4)、股骨颈(NECK)及华氏三角(ward’s)等部位的骨密度(BMD)测定。采用Spss10.0统计软件对结果进行t检验和相关分析统计。结果尿Dpd与年龄呈正相关,与BMD呈负相关。围绝经期尿Dpd较正常对照组增高,绝经后OP尿Dpd显著增高。结论尿Dpd与绝经后OP关系密切,尿Dpd改变可发生在围绝经期,尿Dpd预测危险人群骨量变化早于骨密度。
Objective To investigate the relationship between urine deoxypyridinolate (Dpd) and bone mineral density (BMD) in perimenopausal women to evaluate the clinical value of urinary Dpd in the screening of high risk population of osteoporosis (OP). Methods A total of 53 cases of postmenopausal women were included in this study. 300 postmenopausal women with OP and 200 normal controls were enrolled in this study. Dpd and urinary creatinine (CKD) were measured by enzyme-linked immunosorbent assay (ELISA). The bone mineral density (BMD) of lumbar spine 2 ~ 4 (L2 ~ 4), NECK and ward ’s were measured by Dual Energy Absorbance Spectroscopy (DEXA). Using Spss10.0 statistical software t test results and related statistics. Results Urinary Dpd was positively correlated with age and negatively correlated with BMD. Peripheral menopausal Dpd increased compared with the normal control group, postmenopausal OP urinary Dpd was significantly higher. Conclusions Urinary Dpd is closely related to OP in postmenopausal women. Changes in urinary Dpd may occur in perimenopausal period. Urinary Dpd predicts early bone mineral density changes in at-risk population.