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目的探讨急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)的水平变化及其临床意义。方法采用颗粒增强免疫透射比浊法测定125例急性脑梗死患者的hs-CRP水平,用统计学分析其与急性脑梗死病情轻重、预后的关系,并与130例正常对照组进行比较。结果急性脑梗死患者的hs-CRP水平明显高于正常组(P<0.01);在急性脑梗死患者中,hs-CRP水平也随病情的轻、中、重程度而表现变化,差异有统计学意义(P<0.01);且hs-CRP异常组的病情转归及预后差,而正常组的病情转归及预后良好。结论 hs-CRP水平与急性脑梗死的发生、发展密切相关,hs-CRP水平变化是判断急性脑梗死患者病情及评估预后的敏感指标。
Objective To investigate the changes of serum hs-CRP level in patients with acute cerebral infarction and its clinical significance. Methods The levels of hs-CRP in 125 patients with acute cerebral infarction were measured by particle-enhanced immunoturbidimetry. The relationship between the level of hs-CRP and severity and prognosis of acute cerebral infarction was statistically analyzed and compared with 130 healthy controls. Results The hs-CRP level in patients with acute cerebral infarction was significantly higher than that in the normal group (P <0.01). In patients with acute cerebral infarction, the hs-CRP level also changed with the mild, moderate and severe degree of disease, the difference was statistically significant (P <0.01). The prognosis and prognosis of patients with abnormal hs-CRP group were worse than those with normal hs-CRP group, and the prognosis was good in normal group. Conclusion The level of hs-CRP is closely related to the occurrence and development of acute cerebral infarction. The change of hs-CRP level is a sensitive index for judging the condition of patients with acute cerebral infarction and evaluating the prognosis.