论文部分内容阅读
目的探讨交感神经皮肤反应电位(SSR)曲线下面积对糖尿病周围神经病(DPN)的诊断价值。方法 100例糖尿病患者中,有DPN临床表现的57例为A组,无DPN临床表现的43例为B组,C组35例为正常对照组。3组均行双上肢交感皮肤反应(SSR)检测,对SSR起始潜伏期、波幅、曲线下面积3个参数进行统计学处理。结果双肢或单肢未引出SSR者,A组为29例(50.9%),B组为14例(32.6%),A、B两组差异有统计学意义(P<0.01)。A组与C组对比,A组双侧潜伏期延长(P<0.05)、波幅降低(P<0.01)、曲线下面积减少(P<0.01)。B组与C组对比,B组右侧潜伏期延长(P<0.05)、双侧波幅降低(P<0.05)、双侧曲线下面积减少(P<0.05)。A、B两组曲线下面积的异常率均高于起始潜伏期和波幅。结论 SSR是DPN早期诊断的有效方法,曲线下面积可作为敏感指标,有助于发现亚临床病变。
Objective To investigate the diagnostic value of the area under the curve of sympathetic skin response potential (SSR) on diabetic peripheral neuropathy (DPN). Methods Fifty-seven patients with clinical manifestations of DPN in group A were enrolled as group A, 43 patients without clinical manifestations of DPN as group B, and 35 patients with group C as normal control group. Three groups were performed double upper extremities sympathetic skin reaction (SSR) detection, SSR initial latency, amplitude, the area under the curve of three parameters for statistical analysis. Results There were 29 cases (50.9%) in group A and 14 cases (32.6%) in group B, but there was no significant difference between group A and group B (P <0.01). Compared with group C, group A had longer latency (P <0.05), lower amplitude (P <0.01) and lower area under curve (P <0.01). B group and C group, the right side of B group latency (P <0.05), bilateral amplitude decreased (P <0.05), bilateral area under the curve decreased (P <0.05). The abnormal rate of the area under the curve of A and B were higher than the initial latency and amplitude. Conclusion SSR is an effective method for the early diagnosis of DPN. The area under the curve can be used as a sensitive index to help find subclinical lesions.