论文部分内容阅读
对83名3岁以内的婴幼儿脑性瘫痪(cerebralpalsy,CP)及其母做了TORCH系列的抗体、PCR-DNA/RNA检测和病毒分离。同时做了60名同龄健康婴幼儿作对照。结果表明,CP组TORCH系列检出的阳性率、混合感染率均高于对照组,P<005/001,有显著性差异。<1岁组CP患儿的TORCH阳性检出率显著高于2岁组和3岁组,经方差分析,F=8.74,P<001。CP组TORCH系列阳性检出率与其母的阳性符合率平均为8429%,表明CP患儿的TORCH感染可能与母孕期的垂直传播及生后密切接触传染所致。TORCH感染可致胎儿期和初生期小儿脑发育障碍,可能是此期引起CP的主要因素之一。其机制可能与病毒感染引起神经细胞凋亡有关。
TORCH antibodies, PCR-DNA / RNA detection and virus isolation were performed on 83 infants with cerebral palsy (CP) and their mothers within 3 years of age. At the same time made 60 healthy infants and young children as a control. The results showed that the positive rate and the mixed infection rate of the TORCH series detected in the CP group were higher than those in the control group (P <005 / 001), with significant difference. The detection rate of TORCH positive in CP patients <1 year old group was significantly higher than that of 2 years old group and 3 years old group. By ANOVA, F = 8.74, P <001. The positive coincidence rate of TORCH series in CP group and its mother averaged 8429%, which indicated that TORCH infection in CP children may be caused by the vertical transmission in mother’s pregnancy and close contact with birth. TORCH infection can cause brain development disorders in infants and newborn infants, may be one of the main causes of CP during this period. The mechanism may be related to viral infection caused by nerve cell apoptosis.