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目的探讨非酒精性脂肪性肝病(NAFLD)与胰岛素抵抗(IR)的关系。方法NAFLD组52例,非NAFLD组50例,比较两组间BMI、WHR、TC、TG、CRP、HDL-C、LDL-C、ALT、Cr、FBG、FINS和HOMA-IR的差异,并进行Logistic回归分析。结果NAFLD组与非NAFLD组在BMI(26.7±2.3与22.4±2.5,P<0.01)、WHR(0.94±0.06与0.83±0.05,P<0.01)、TG(2.4±0.6与1.8±0.6,P<0.01)、ALT(37.3±8.3与28.1±7.2,P<0.05)、FBG(6.2±1.4与5.2±0.7,P<0.01)、FINS(23.6±13.6与8.6±3.5,P<0.01)、HOMA-IR(6.7±4.7与2.0±1.6,P<0.01)的差异有统计学意义,Logistic回归分析显示BMI(P<0.01)、WHR(P<0.01)、TG(P<0.01)、ALT(P<0.05)、HOMA-IR(P<0.01)是NAFLD的独立影响因素。结论BMI、WHR、TG、ALT、HOMA-IR是NAFLD的独立影响因素。
Objective To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Methods Fifty-two NAFLD patients and 50 non-NAFLD patients were enrolled in this study. The differences of BMI, WHR, TC, TG, CRP, HDL-C, LDL-C, ALT, Cr, FBG, FINS and HOMA- Logistic regression analysis. Results Compared with non-NAFLD group, NAFLD group had significantly higher BMI (26.7 ± 2.3 vs 22.4 ± 2.5, P <0.01), WHR (0.94 ± 0.06 vs 0.83 ± 0.05, P <0.01) 0.01), ALT (37.3 ± 8.3 vs 28.1 ± 7.2, P <0.05), FBG (6.2 ± 1.4 vs 5.2 ± 0.7, P <0.01), FINS (23.6 ± 13.6 vs 8.6 ± 3.5, Logistic regression analysis showed that BMI (P <0.01), WHR (P <0.01), TG (P <0.01) and ALT (P <0.01) were significantly different between IR (6.7 ± 4.7 vs 2.0 ± 1.6, P <0.01) 0.05). HOMA-IR (P <0.01) was an independent factor of NAFLD. Conclusion BMI, WHR, TG, ALT and HOMA-IR are the independent factors of NAFLD.