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据国外文献报道,植物中的鞣质能损害肝脏,因此在烧伤的治疗中一般不用含鞣质的制剂。近年国内在治疗烧伤特别是在大面积烧烫伤中大量使用四季青、虎杖等含鞣质的中草药制剂,会不会引起中毒?答:近年来国内研究了民间用于烧伤烫伤的中草药,分别提取其鞣质,并作了大量的药理试验,发现中草药中的鞣质有两类:一类为具有酯状结构的水解型鞣质(含于五倍子、石榴皮,地榆、酸枣树皮等中),对肝脏具有不同程度的毒性,引起实验动物的死亡,另一类为缩合型鞣质(含于虎杖,四季青、儿茶、梹榔、棕榈等内),其化学结构复杂,碳与碳之间有缩合键,与稀盐酸反应后或在酒精中均可缩水转化成鞣
According to foreign reports, tannins in plants can damage the liver. Therefore, tannin-containing preparations are generally not used in the treatment of burns. In recent years, Chinese herbal medicines containing tannins, such as hollyhine and polygonum cuspidatum have been widely used in the treatment of burns, especially in large-area burns, will it cause poisoning? A: In recent years, Chinese herbal medicines used in burns have been studied in folks and extracted separately. The tannins and a large number of pharmacological tests were conducted and it was found that there are two types of tannins in Chinese herbs: one is a hydrolyzed tannin with an ester-like structure (contained in gallnut, pomegranate, mantle, and jujube bark etc. ), The liver has different degrees of toxicity, causing the death of experimental animals, the other is the condensed type of tannins (including Polygonum cuspidatum, Sijiqing, catechu, wolfberry, palm, etc.), its chemical structure is complex, carbon and There is a condensation bond between the carbons. After reacting with dilute hydrochloric acid or in alcohol, it can be converted into hydrazine.